Minami-senju is a densely packed residential neighborhood in Arakawa Ward just across the Sumida River from Kita-Senju.
Although the area is a bit bland, with lots of wide roads and tall apartment blocks, it does have excellent shopping, with lots of large format big-box stores including a home center mainly located around Lala Terrace to the northeast of the station.
In the Edo period, Minami-Senju was the northern gateway to the capital, so like the southern gateway near Shinagawa, it was the site of a major execution grounds—the Kozukappara Execution Grounds. Today the only thing that remains is a memorial, just to the south of the station.
The banks of the Sumida River in nearby Shioiri Park are a great place to enjoy the annual Sumida River Fireworks Festival which takes place further down the river near Asakusa.